Bovine leukemia virus (BLV) is an infectious agent that has taken enormous economic toll on cattle breeding worldwide. Effective breeding requires the search of molecular and genetic markers of susceptibility to this infectious disease. CXC chemokines and their receptors play an important role during different stages of LV infection.

Agro-industrial complex - a set of interrelated sectors of the economy involved in the production, processing of agricultural products and bringing it to the consumer. Agriculture occupies a special place in the life of the region, as it provides food and consumer goods. The development of agriculture significantly affects the level of national welfare, as its products account for about 60 % of goods in trade. The authors assess the current conditions and problems of agro-industrial complex of Tomsk region, determine the prospects of development of the complex, based on the implementation of the economic mechanism of sustainable development. A number of problems of development of agro-industrial complex in Tomsk region are revealed, some ways of its improvement are offered. The solution of problems of development of agro-industrial complex will contribute to the food security of the region and the country as a whole, focus on meeting the demand of the domestic market and increasing exports, improving the level and quality of life of the rural population.

In taste and biological evaluation of all monilinia and polimernye varieties of honey collected by bees from plants of Western Siberia, received the highest recognition in our country and in the international market. Honey from Mountain Shoria was demonstrated three times at the world congresses on beekeeping and each time received the highest rating and was awarded with a gold medal. The awards were presented in 1965, at the XX Congress in Bucharest, at the XXIII Congress in Moscow in 1971 and at the XXXXVI Congress in Korea in 2016.

The starting material for the production of natural dyes are mainly plants. Coloring substances are usually obtained from various parts of plants: flowers, berries, roots, leaves containing pigments, the color of which is due to the presence of compounds such as anthocyanins, carotenoids, chlorophyll, flavonoids, etc. The most promising plant from the point of view of obtaining a yellow colorant is a medicinal calendula (Calendula officinalis L). Coloring pigment is mainly in the epidermis of the corollas of flowers and belongs to the group of carotenoid dyes, giving a yellow color. Its content in the flowers of calendula depends on the variety and growing conditions. Inflorescences of calendula officinalis contain carotenoids 2.8 %, the organic acid is 7.8 %, tannins to 0.02 %, essential oil of 0.03 %, mucus 4 %, ascorbic acid was 4.2 %. The chemical composition of calendula flowers, allows them to be used for dye. A method of extracting coloring substances from the inflorescences of calendula is developed.

The results of an analytical review of global scientific research on the state of the development of a severe intestinal disease - celiac disease caused by allergies to wheat proteins in genetically predisposed people. As an alternative cause of the occurrence of this disease, a widely used chemical substance was considered - the herbicide glyphosate, presumably causing the disease in people who initially had no genetic prerequisites for the development of celiac disease.

The article analyzes data on the effect of fungicidal and herbicidal preparations on grain quality and productivity of spring wheat. Timely and high-quality use of plant protection products from harmful organisms can improve not only the productivity of spring wheat, but often the quality of grain. In the years of mass spread of aerogenic infections, the use of fungicides in wheat crops can increase the protein content of the grain, as the leaves are longer and more productive photosynthesize. Under these conditions, the increase of the content of gluten on the use of systemic multi-component fungicide in the phase of the flag leaf was 3 %, in case of moderate development of disease was 2.4 %. The yield of flour increased by 5-7 %, and in some years there was an improvement in baking evaluation from satisfactory on the control variant to good on the variant with using a system fungicide. Correlation dependence of disease development and gluten content in grain was characterized as very strong and very strong inverse (r=0.88-0.98). In years with the strong development of leaf spots and the defeat of straw linear rust requires double use of fungicides to preserve the crop and grain quality. Long-term tests of post-emergence herbicides have shown that the use of these drugs in the framework of the regulations of their use did not worsen the quality of spring wheat grain, but also a significant stable positive effect on this indicator was not observed.

The influence of nutrient media of different component composition on ket potato varieties and Rogachev Memory was studied. It is shown that in the conditions of culture in vitro potato plants of the studied varieties show variety specificity when cultivated on nutrient media of different composition.

The level of development of grain farm, the market of his production in many respects defines degree of satisfaction of need of the population for food in the respective regions of the Russian Federation. In many respects causes organizational actions for his regulation and socially - economic and economic efficiency of functioning of agro-industrial complex in general. Kabardino - Balkaria has considerable potential opportunities for satisfaction of the needs for grain and products of his processing, increase in deliveries to the internal and external markets. However for the successful solution of the specified problems in agro-industrial complex of the republic still there are tasks of restriction of the harm done to agrotsenoza from outside sorno - field vegetation on crops of the main field cultures the task was set For us: to define extent of suppression of weed plants by means of agrotechnical (without attraction of chemical weeding) methods under a condition when especially harmful perennials (гумай, types of sow-thistles, etc.) don’t constitute danger to crops of agricultural field cultures. Therefore in our long-term (201-2016) the researches conducted by method of field experiment have received the results demonstrating efficiency of bezgerbitsidny technology on field, littered with juvenile weeds [1; 2].

In agro-industrial complex in most agricultural enterprises the expenses connected with production often exceed indicators of revenues of branch. Our researches have shown that there are some opportunities of change of this situation and, first of all, this introduction in production of effective, low-cost ways of processing of the soil. they significantly reduce potential contamination of an arable layer of earth, negatively don’t influence processes of formation of efficiency of culture, provide increases in level of profitability and net income against the background of saving of diesel fuel on one third. As the proof stated by us long-term field experiments in the conditions of a steppe zone of Kabardino-Balkaria are made (the item. Skilled the Tersky Region of KBR) 2009-2011 in these researches it is shown influence of ways of the main processing on potential contamination of the soil, productivity and economic efficiency of production of grain of corn.

Studies conducted in 1996-2017. on the black soil leaching-locenih forest-steppe of the Ob region in multi-factor stationary field experiment in Sibnica. Crops were cultivated in 4-full rotation: from 1996 to 2006 «steam-winter rye-wheat-wheat”; since 2007 winter rye was replaced with wheat:”steam - wheat - wheat - wheat». The mechanical treatment of soil in fields of crop rotations: 1) plowing in a couple of 25-27 cm, under the wheat (the second and third culture after pairing) is 20-22 cm; 2) subsurface treatment stands, Cibima in a couple of 25-27 cm, under a wheat - 20 to 22 cm; 3) minimum tillage cultivator «Step-UC» to a depth of 10-12 cm for all crops; 4) no autumn treatment. SASO of-attorney of the crops studied in the three backgrounds of chemicals - extensive, low-intensive and intensive. The high efficiency of herbicide treatment of spring wheat with a tank mixture of Puma-super and Elant - premium against the main types of weed vegetation is shown. Against the background of the use of herbicides for all years of research, there were no significant differences in the number of weeds in the variants with fertilizers and without fertilizers, as well as in the contamination of different variants of the main tillage. The average contamination of spring wheat crops in the grain-fallow crop turnover for 20 years of research on an intensive and low-intensity background in all variants of the experiment did not exceed the threshold of harmfulness. On the background without herbicides the number of weeds was steadily higher than in the horn of harmfulness in all embodiments, the main processing of the soil. The maximum of weeds has always been noted in the variant without fall tillage - from 12.6 % in the first crop rotation to 35.3 % in the third, and the minimum - for plowing (from 7.1 to 21.8 %). The maximum biological and economic efficiency of herbicide treatment was observed on an intensive background in the tillering phase of spring wheat (92.5 %). It is shown that the use of herbicides on spring wheat without fertilizers and fungicides in the conditions in Western Siberia is advisable only for grain predecessors with a planned yield of at least 15 t/ha.

Research work on hyperhaline lakes was started in 1977. Commercial interest in artemia (at the stage of cysts) as a starting feed for hydrobionts served as a basis for monitoring studies of hypergalin lakes of the Altai Territory. Lake Dushnoye is located in the Nizhne-Kasmalinsky system of lakes, which belongs to the vast Kulunda-Kasmalinsky basin of Artemia lakes, which is the basis of the resource base of artemia in the south of Western Siberia in terms of the number of water bodies. As a result of complex hydrobiological surveys in the spring period from April to May 2018, the dynamics of the indices of the number of different stages of development of the crustacean (nauplii, juvenile, pre-adult, adult, cysts, summer eggs), their percentage ratio, size-age structure of the population, productivity of the crustacean Artemia Leach, 1819, morphometric parameters of mature individuals and cysts of Lake Dushnoye in the Altai Territory in comparison with similar indicators for 2017. The temperature regime at the beginning of the vegetation period of the current year was unfavorable for the development of artemia in lakes, which led to low numbers of crustaceans. According to the results of monitoring studies of the hypergalin lake of the Altai Territory in the spring (April and May 2018), during the development of the first generation of crustaceans, a depressive the state of development of the population of the brine shrimp in Lake Dushnoye, Volchikhinsky district. A potential stock of Artemia cysts is given.

On the territory of the south-east of Western Siberia (Tomsk Region), the features of the species biology are analyzed: abundance, dendroactivity, biotopic confinement, the device of a dens. Scuffs and scraps of bark left by the bear are marked on fir - 80 % and cedar -20 %. Bears were marked mainly by trees that are in the edge of the forest stand along the fringes, forest roads, winter roads and quarter walkways, animal paths. Traces of bear activity located at a height of 156 cm to 242 cm indicate the manifestation of food, comfortable and marking dendroactivity. The burlogs are confined to hard-to-reach places - forest heaps, cuttings, found in coniferous forests eaten by silkworms, on old garbage. The bergs are located beneath the roots of large trees: birches, cedar, less often under fallen trees, ovaries and fallen trees of cedar, aspen. The exit from the den is mainly directed to the south. The internal dimensions of the den often vary: length from 150 to 350 cm, height - 80-215 cm, width - 130-300 cm. In the litter - grass (33.3 %), moss (21.6 %), leaves (17, 6 %), branches (9.8 %), needles (7.8 %).

The aim of the research is to study the influence of different seasons of birth on the productivity of Hereford bulls for the implementation of various technological solutions. The object of the study were Hereford bulls from birth to 16 months of age in LLC «Andrianovsky» of the Republic of Khakassia. By pairing custom-made 100 cows with the bull in 2015-2016 was obtained 53 bull. Of these, 2 groups of 20 bulls were formulated for control cultivation: 1st-animals born from January to April, and 2nd - from October to December. Assessment of the dynamics of live weight of test bulls of both groups shows that the average age of 16 months met the requirements of the elite class. While significant differences between the groups in live weight over the accounting periods was not observed. Bulls of the 1st group had a live weight of 462.9±10.9 kg, the 2nd group-438.6±11.2 kg. the Exception is only the average daily increase from 12 to 16 months. There was a significant superiority of bulls born in the period from January to April (P<0.001). The greatest relative increase was observed in animals of the 1st group aged from birth to 16 months, i. e. for the entire period of cultivation, and bulls of the 2nd group only in the period from 8 to 12 months, when this group, using the potential of pastures, is ahead of the average daily growth of their peers. Season of birth has no significant effect on the ability to achieve Hereford bulls optimal body weight. This proves the possibility of using Hereford animals in the implementation of new promising technological solutions.

The results of long-term researches received in stationary field experiment on the Chernozem leached by the average loam of the Novosibirsk Ob region are presented. It is established that the studied systems of basic mechanical treatment did not affect the phosphorus alienation by the grain of spring wheat of Novosibirsk 29. Chemicals significantly increased the removal of this element, which was most clearly seen in the final wheat in the crop rotation «steam - wheat - wheat - wheat».

Seven species of three genera of perennial grasses for lawn agrophytocenoses on ashen-gray soils in a taiga zone were studied for the first time. The objective of the study was to identify the best samples of lawn grasses that can effectively use the agro-resource potential of natural climatic conditions of the research area. The width of a leave (texture) was used as one of the main indicators for the assessment of the decorativeness of a lawn grass stand. The samples were studied according to the methodological instructions of the All-Russian Williams Fodder Research Institute. Samples distinguished by grass stand high decorativeness were identified. Samples of meadow grass, bent grass and fescue grass, a variety of English bluegrass Yuventus are distinguished by complete winter hardiness. The lowest samples of meadow grass were varieties Yaskia, Limonsine, Barkenta; English bluegrass - Sport, Fiesta, Yuventus; bent grass - wild populations K-14272, K-14273, K-14265. Samples of English bluegrass - Yuventus, Primevere, K-14233 - are distinguished by the highest decorativeness of the grass stand in terms of the texture.

Hematological profiles of imported Holstein bulls were studied twice after quarantine in order to control the process of adaptation of animals to new environmental conditions. It is shown that after quarantine in animals there was an increased content of leukocytes and hemoglobin in the blood relative to the physiological norm, which reflects the change in the functional state of the organism of bulls in connection with the change of the environment. The leukocyte content of 1/4 of imported bulls remained almost unchanged during the study period, and in more than 66 % of cases its subsequent decrease to the upper limit of the norm was observed. At the same time, it was noted that in some animals the decrease in the level of leukocytes occurred smoothly, while in others there were sharp falls. There were cases of a sharp increase in the number of lymphocytes (up to 93 %) a month after the quarantine of animals on the background of a decrease in neutrophils. The average content of erythrocytes in the blood was included within the boundaries of the reference values. Variation of this indicator was not high, in 83.3 % of animals it remained almost at the same level. The ratio of the volume of shaped elements and blood plasma in the studied bulls did not go beyond the physiological norm. The number of platelets in the blood of all bulls was within the reference limits. The imported bulls in the initial period of adaptation observed changes in the hematological profile, and subsequently formed a tendency to normalize the level of hematological parameters, which in the future will allow the animals to realize the genetic potential.

Time series models are one of the most commonly used forecasting tools in the agricultural economy. In this case, the future values of the variable are function of the past values of the same variable. In other words, there are autoregressive processes. The dynamic of grain yields in the North-Kazakhstan and Kostanay regions of Kazakhstan demonstrate very similar statistical properties. In both cases, there is a positive linear trend, the cyclical development of the process is clearly discernible. Serious attention should also be given to the existence of a cycle in the dynamics of the dispersion level of crop yields. These stochastic features of the indicator should be taken into account in agricultural forecasting.

For the detoxification of mycotoxin aflatoxin B1 in the feeding of poultry, various probiotic feed preparations based on living beneficial microorganisms and antioxidants, which significantly improve the intestinal microflora, immunity, digestibility and digestibility of nutrients feed, which has a positive effect on productivity. This article presents experimental data that suggest that to increase the growth rate, digestibility and digestibility of nutrients in the feed for quails based on barley grain, sorghum and soybean meal with a tolerant level of aflatoxin B1 should be added together probiotic Bioximin «Chicken» at a dose of 1500 g/t and vitamin C at a dose of 500 g/t feed. In comparison with the control analogues in poultry of 3 experimental groups in increasing the safety of livestock by 6 %, the average daily gain of live weight - by 12.48 % while reducing feed consumption per 1 kg of increase - by 11.84 %. Feeding probiotic and vitamin C contributed to a significant (p<0.05) increase in the digestibility coefficients of dry matter by 3.08 %, organic matter - by 3.10 %, crude protein - by 3.30 %, crude fiber - by 3.06 % and BEV - by 3.33 %. Better digestibility of raw protein of feed was promoted by joint additives of probiotic and antioxidant.

In the article, data on the distribution of anoplodsefalidosis of horses are given. Anoplodsefalidozy horses are widely distributed in the northern and central zones of the Republic of Sakha (Yakutia). The species composition of these cestodes is represented by 3 species: Anoplocephala magna, Anoplocephala perfoliata and Paranoplocephala mamillana. Of the 10 species of oribatid ticks found in the pastures of six species, anoploccephalidae, Achheteria coleoptrata, Scheloribates latipes, Scheloribates laevigatus, Galumna obvia, Ceratosetoides cisalpinus, Testocepheus velatus have been registered as intermediate hosts. The highest reproductive activity of oribatids occurs in May-June, which contributes to the massive infection of horses. In laboratory conditions, at a temperature of 28̊C and a relative humidity of 70-80 %, cysticercoids in mites form in 35-40 days.

The genotypic characteristics of the Sapphire genotype (SG) pigs and their hybridization with the вoars Landras (L) and Duroc (D) of 2-breed (SGхL) and 3-breed [(SGxL) xD] hybrids by genes: FABR-H, FABR-D, Ms4r, LEP, ECR, RYR-1 was investigated. In SG animals, the frequency of the ECRGG genotype, which is increased in comparison with 2- and 3- breed hybrids, is 0.41-0.54. Two-breed hybrids are characterized by a higher frequency of the genotype FABP HH (by 0.22-0.27) and FABP dd (by 0.27-0.39) than SG and three-breed. The peculiarity of the 3-breed hybrids (SGxL) xD is the higher frequency of the homozygous genotype Ms4r AA (by 0.24-0.34), and the lower frequency of the heterozygous Mc4r AG (by 0.19-0.43) compared with pure SG and 2-breed hybrids. The polymorphism of the LEP and RYR-1 genes in the compared groups of pigs is mainly represented by the desired genotypes LEPTT (71-75 %) and RYR-1NN (71-86 %). The indices of genetic similarity between the SG and hybrids were determined. The most significant differences were found between 2-breed and 3-breed hybrids (0.7634 ± 0.0613), which can be explained by the presence of blood of the breed D. General homozygosity (GH ) in pigs SG was 24.89 %, in 3-breed hybrids - 14.6 %. The genotypic structure of stress-resistant and stress-sensitive animals and associative connection of genotypes with energy of growth are revealed. Piglets with genotype FABPHH, resistant to stress, during the growing period surpassed their peers with the FABPHh and FABPhh genotypes by an average daily gain of 81-139 g, sensitive to stress by 134 g. Animals with the FABPDD genotype, stress-resistant, had the highest energy of growth (593 g), which was higher than in peers with the homozygous genotype FABP Ddd by 91 g and heterozygous FABP DDd by 157 g. Among the piglets sensitive to stress, individuals with the LEPTT genotype had a higher growth energy of 87 g compared to heterozygous LEPTC. Stress-resistant pigs with the RYRNn genotype outperformed homozygous peers of RYRNN in this indicator by 95 g. Among the carriers of the Mc4r and ECR genotypes, no differences in growth energy of the pigs were detected.

Northern reindeer breeding is the main branch of agro-industrial complex in the northern regions of the Russian Federation. Infectious diseases are an important factor, that decreases the profitability of this branch. Brucellosis is the most often occurring disease in the infectious pathology there. The focal areas of brucellosis that persist over the vast territory of the Russian High North constitute a danger of carrying the infection into satisfactory herds and its subsequent spread among susceptible animals. This makes immune protection of reindeer against brucellosis necessary and reasonable. The live vaccine based on weakly agglutinogenic strain B.abortus 82 is officially adopted as a means for reindeer immunization. The specificity of the northern reindeer breeding does not always allow to organize veterinary measures systematically and on a mass scale. It often happens that vaccinated reindeer are included in diagnostics, produce positive diagnostic responses and are considered to be infected with brucellosis. In order to objectively evaluate epizootic situation in terms of brucellosis in herds, to prevent losses from unreasonable reindeer disposal and to increase the production quality control a differential diagnostics of blood serum samples for brucellosis of the examined livestock was conducted. The possibility of including in the complex of diagnostic test some additional tests, which allow to differentiate vaccinal responses from infection processes in animals was studied. It was revealed that from 10 to 31 percent of animals having positive responses were found in the reindeer herds situated on the brucellosis unsatisfactory territory. The use of R brucellosis antigen in serological tests allowed to discover that the majority (61.8 %) of positive responses in animals are connected with postvaccinal process.

The choice of breed of cattle for production is the defining factor of efficiency of branch. Unfortunately this element hasn’t received due scientifically based, both technological, and economic assessment. It has historically developed that a strategic indicator of a condition of dairy cattle breeding is the size of a yield of milk on a cow in a year, all other parameters aren’t of particular importance. On this background, on the leading place the golshtinsky breed which by right takes this position has moved forward and in recent years I became one of the most demanded. At the same time, the effectiveness of use of manufacturing bulls of red and motley golshtinsky breed on a uterine livestock of the local red steppe cattle is defined by heredity of the picked-up animals, their compatibility, conditions of cultivation and fitness of hybrids to the accepted technology of contents. Therefore in selection and breeding work it is necessary to consider concrete climatic and economic and economic service conditions of animals. It should be noted that in most cases, economic entities don’t provide necessary fodder, technological conditions of keeping. As a result, sharp decrease in efficiency, use duration, low profitability that becomes one of arguments of reduction of a livestock, refusal of production of milk, reduction of employment of country people. The last becomes one of the most important indicators of social vulnerability, especially, in the southern densely populated regions of the country.

Rats Wistar line were found to be a good laboratory model for the BLV infection pathogenesis studying. At the initial stage of infection, the rats’ first generation offspring were born healthy and colostral immunity protected them from infection for at least a month. Transplacental transmission of the virus to the rats’ second generation offspring was established in 30-33 % of experimental animals. The results of hematological studies have shown that in animals of experimental groups, thrombocytosis progressed over time and the average volume of platelets increased, which may be evidence of the megakaryocytic leukemia development. In some cases, there were signs of allergy, hemolytic anemia, lymphocytic leukemia. The most significant changes were found in the offspring of experimental rats.

The aim of the authors was to determine the effect of the selenium-containing preparation «E-selenium» and the homeopathic preparation «Ovariovit» on the reproductive indices of sows, as well as the tasks: to study the morpho-biochemical and immunological status of clinically healthy animals; evaluate the performance of the sows under investigation. The experiment on the basis of a large industrial pig complex in the Omsk region using healthy sows selected according to the principle of analogues allowed us to establish that the simultaneous application of the studied complex of drugs allows achieving high productive results. The positive effect of the preparations is indicated by the production parameters of the experimental group with a significant difference from the control group, consisting in a shortening of the farrowing period (P <0.01); an insignificant increase in the number of live-born piglets, the weight of the nest at birth, the average daily gain, and the average live weight of the piglets during weaning. The introduced complex «E-selenium» and «Ovariovit» with the purpose of correction of reproductive functions of sows positively influences blood indices, so on the 30th day after administration of drugs the amount of creatinine in the sows of the experimental group significantly decreased to 320.18 ± 8.69 against 401, 5 ± 13.43 in the control group (P≤0.001); a significant increase in the content of total protein in the blood of the test animals was observed by 9 % (P≤0.05). Immunological studies have confirmed the beneficial effect of selenium-containing and homeopathic preparations, namely on the 30th day after the introduction of the complex it was found that in the sows of the experimental group there was an increase in the number of leukocytes by 50 % and erythrocytes by 25.4 % (P <0.05) with values in the control group of animals. There was also a significant increase in absolute lymphocyte count in the peripheral blood. At the same time, an increase in the number of lymphoid cells was due to all populations. Especially it is necessary to allocate cytotoxic T-lymphocytes, the concentration of which relative to control increased by 2.6 times (P <0.05).