DYNAMICS OF BIOCHEMICAL INDICATORS OF WISTAR LINE RATS UNDER PARENTERAL BLV INFECTION

Abstract

Biochemical studies of blood ofrats of Wistar line after intraperitoneal infection of their lymphocytes from BLV-infected cows showed an increase in the creatinine figures 14.5 and 22.5 % urea and 11.9 %; the decrease in the fraction of albumin 27.8 and 39.3 % with a reduction in total protein of blood is 35.4 %; the decrease in the activity of blood amylase to 21.3 % and the content of blood glucose is 18.4 %; the increase in liver enzymes ALT and AST 1.4/the 2.3 and 1.7/3.2 times, respectively, with increased LDH activity in 1,3 times, as well as the increased content of bilirubin in the blood in 2.8 and 2.6 times compared with control. In the offspring of BLV-infected rats, the biochemical parameters of blood changed in a more significant range than in their parents. A comparative analysis of data from biochemical studies of rat blood revealed prerequisites for the development of endogenous intoxication in animals of the experimental groups, characterized by the presence of markers of impaired activity of the hepatobiliary system andfiltration-reabsorption function of the kidneys, as well as signs of the development of destructive processes and hemolytic anemia. Our data allow us to recommend an intraperitoneal method of infecting laboratory rats with a suspension of lymphocytes from infected cattle to reproduce experimental BLV infection.