New immunomodulatory preparations based on RNA to treat viral infections
https://doi.org/10.31677/2311-0651-2023-42-4-78-89
Abstract
New experimental antiviral preparations are developed based on a molecular structure consisting of single-stranded and double-stranded RNAs from different sources and an outer envelope based on dextran with specific isotropic agents. An affection of developed molecular structure preparations on physiological indicators variety in laboratory animals to obtain data on the tolerance of compositions was investigated. It has been shown that administering higher doses of experimental preparations to animals doesn`t cause or lead to short-term and minor deviations in their condition. An application of the method of specific interferon-inducing activity determining in the study of antiviral and other interferon inducers characteristics may be used for estimation of criteria like the minimal effective interferon-inducing dose (MEID) and the modified chemotherapeutical index (mCTI), required for a complete characterisation of drugs.
About the Authors
V. V. Ermolaev
FSBU SSC VB «Vector»
Russian Federation
Russian Federation
Junior Research Fellow.
G. G. Shimina
FSBU SSC VB «Vector»
Russian Federation
Russian Federation
Research Fellow.
Yu. S. Alikin
FSBU SSC VB «Vector»
Russian Federation
Russian Federation
Doctor of Biological Sciences, Professor, Senior Research Fellow.
S. G. Gamaley
FSBU SSC VB «Vector»
Russian Federation
Russian Federation
Head of Department.
L. R. Lebedev
FSBU SSC VB «Vector»
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor Institute of Medical Biotechnology.
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Review
For citations:
Ermolaev V.V., Shimina G.G., Alikin Yu.S., Gamaley S.G., Lebedev L.R. New immunomodulatory preparations based on RNA to treat viral infections. Innovations and Food Safety. 2023;(4):78-89. (In Russ.) https://doi.org/10.31677/2311-0651-2023-42-4-78-89
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