BLOOD BIOCHEMICAL PARAMETERS OF RATS – WISTAR LINE UNDER THE BLV EXPERIMENTAL INFECTION
https://doi.org/10.31677/2311-0651-2019-24-2-69-75
Abstract
<p>It is founded that аn outbred Wistar line rats are susceptible to oral infection with bovine leukemia virus. Pathognomonic for leukemia changes such as neoplastic processes, as well as hyperplasia, adenocarcinoma, mastocytoma and fibrosarcoma in spleen were revealed in rats, when feeding them milk of BLV-infected and affected with leukemia cows. Progressive signs of intoxication, endocrine disorders and development of malignant processes were revealed by biochemical studies of the rats’ blood serum, regardless of whether the milk of infected or affected with leukemia cows was fed to them. In the offspring of experimental animals pronounced signs of liver, kidney and myocardium damages were observed.</p>
About the Authors
E. S. Krasnikova
Saratov state agrarian University named after N. I. Vavilov
Russian Federation
Doctor of Veterinary Sciences, Associate Professor
Russian Federation
Doctor of Veterinary Sciences, Associate Professor
A. V. Krasnikov
Saratov state agrarian University named after N. I. Vavilov
Russian Federation
Doctor of Veterinary Sciences, Associate Professor
Russian Federation
Doctor of Veterinary Sciences, Associate Professor
R. V. Radionov
Saratov state agrarian University named after N. I. Vavilov
Russian Federation
Assistant
Russian Federation
Assistant
D. A. Artemev
Saratov state agrarian University named after N. I. Vavilov
Russian Federation
Post-Graduate Student
Russian Federation
Post-Graduate Student
V. I. Okolelov
Omsk state agrarian University named after P. A. Stolypin
Russian Federation
Doctor of Veterinary Sciences, Professor
Russian Federation
Doctor of Veterinary Sciences, Professor
References
1. Miller J, Miller L, Olson C, Gillette K. Virus-like particles in phytohemagglutinin-stimulated lymphocyte cultures with reference to bovine lymphosarcoma // J Natl Cancer Inst. – 1969. – № 43. – Р. 1297–1305.
2. Panei CJ, Takeshima S, Omori T, Nunoya T, Davis WC, Ishizaki H, Matoba K., Aida Y Estimation of bovine leukemia virus (BLV) proviral load harbored by lymphocyte subpopulations in BLV-infected cattle at the subclinical stage of enzootic bovine leucosis using BLV–CoCoMo-qPCR // BMC Vet Res. – 2013. – № 9. – Р. 95.
3. Panei C, Tassara F, Pérez Aguirreburualde M, Echeverría M, Galosi C, Torres A, H. J. E. Sila. Seroprevalencia de infección por el virus de leucosis bovina durante 2015 en rodeos de cría de la Zona Deprimida del Río Salado, provincia de Buenos Aires // Analecta Vet. – 2017. – № 37. – Р. 65–68.
4. Enzootic Bovine Leukosis In: Manual of Diagnostic Tests and Vaccines for Terrestrial Animals, Paris: OIE. – 2004. – Р. 729–738.
5. Ruiz V, Porta NG, Lomónaco M, Trono K, Alvarez I. Bovine Leukemia Virus Infection in Neonatal Calves. Risk Factors and Control Measures // Front Vet Sci. – 2018. –№ 5. – Р. 267.
6. Gulyukin M. I., Kozyreva N. G., Ivanova L. A., Stepanova T. V., Klimenko A. I., Kovalenko A. V., Drobin Y. D., Vasilenko V. N. Experimental interspecies transmission of the bovine leukaemia virus // Voprosy virusologii. – 2015. – № 60 (5). – Р. 32–37.
7. Smirnov P. N. Perfect model development of leukemia in cattle: materials own research // Voprosy normativno-pravovogo regulirovaniya v veterinarii. – 2015 – № 2. – Р. 80–82.
8. Petar Dimitrov, Liliya Yossifova, Elena Gardeva, Aneta Todorova, Rumen Valtchovski, Anton Kril, Russy Russev Bovine leukemia virus infection in laboratory animals // Comptes rendus de l’Académie bulgare des sciences: sciences mathématiques et naturelles. – 2009. – № 62 (8). – Р. 965–970.
9. Altanerova V, Portetelle D, Kettmann R, Altaner C. Infection of rats with bovine leukaemia virus: establishment of a virus-producing rat cell line // J Gen Virol. – 1989. – № 70. – Р. 1929–1932.
10. Boris-Lawrie K, Altanerova V, Altaner C, Kucerova L, Temin HM. In vivo study of genetically simplified bovine leukemia virus derivatives that lack tax and rex // J Virol. – 1997. – № 71. – Р. 1514–1520.
11. Krasnikova E. S., Krasnikov A. V., Radionov R. V., Belyakova A. S., Okolelov V. I. Hematological parameters of rats – Wistar line under the BLV experimental infection // Innovations and Food Safety. – 2018. – № 4. – Р. 139–146.
12. HANDBOOK. Physiological, biochemical and biometric parameters of the norm of experimental animals / edited by doctor of medical Sciences, Professor Makarov V. G. and doctor of medical Sciences Makarova M. N. – SPB.: Publishing house «LEMA», 2013. – 116 p.
13. Ermolin A. E. The condition of the pituitary-gonadal system in men with acute leukaemia. Dis. … kand. med. sciences». – 2002. – P. 24.
14. Pavlova А. I., Smirnov P. N., Koriakina L. P., Garmatarova T. V., Kotliarova O. S., Razymnaia V. E., Romanov P. L. Comparative indices of T-and B-lymphocyt content, immunoglobulins of main classes and circulating immune complexes (CIC) in infected BLV and conditionly-pathogenic microflorous of cows // Innovations and Food Safety. – 2017. – № 1 (15). – Р. 17–21.
15. Rozhkov O. A., Borovoy V. I., Smirnov P. N. Trostyansky I. V., Sinyatkin N. V., Leonova M. A., Agarkova T. A., Pogrebnyak V. I., Garmatarova T. V., Hramtsov V. V., Shkil N. N. Influence kontsentranta fulvic acid on morfobiohimicheskie indicators cattle blood infected with BLV // Innovations and Food Safety. – 2016. – № 2 (12). – Р. 5–10.
16. Smirnov P. N. Khramtsov V. V., Mager S. N. Razumovskaia V. M. A. Amirokhov Tiynkov I. V. Immuno morphological changes accompanying the development of hematological malignancies of humans and animals // Innovations and Food Safety. – 2017. – № 4 (18). – Р. 39–50.
Review
For citations:
Krasnikova E.S., Krasnikov A.V., Radionov R.V., Artemev D.A., Okolelov V.I. BLOOD BIOCHEMICAL PARAMETERS OF RATS – WISTAR LINE UNDER THE BLV EXPERIMENTAL INFECTION. Innovations and Food Safety. 2019;(2):69-75. (In Russ.) https://doi.org/10.31677/2311-0651-2019-24-2-69-75
Views:
341
Email this article 