METHOD OF DETERMINING THE IMMUNOGENIC ACTIVITY OF LIVE VACCINE AGAINST RABIES IN WILD ANIMALS IN MICE
https://doi.org/10.31677/2311-0651-2019-24-2-53-57
Abstract
<p>The results of alternative studies on the immunogenic activity of live rabies vaccines for oral immunization of wild carnivorous animals are presented. The method of evaluation of immunogenicity using a model of oral immunization in mice with experimental infection control rabies virus CVS in the dose of 10–100 MLD<sub>50</sub>/0,03 ml. Once entered immunizing dose for white mice, weighing 12–14 g were 56.200 MLD<sub>50</sub>, the titers of VNA ranged from 1:6 to 1:16 (3,0–4,0 log2) and above.</p>
About the Authors
V. A. Babak
PCV «NCB»
Kazakhstan
Candidate of Veterinary Sciences
Kazakhstan
Candidate of Veterinary Sciences
A. A. Gusev
PCV «NCB»
Kazakhstan
Doctor of Veterinary Sciences, Corresponding member of RAS, Professor
Kazakhstan
Doctor of Veterinary Sciences, Corresponding member of RAS, Professor
I. A. Puntus
PCV «NCB»
Kazakhstan
Junior Researcher
Kazakhstan
Junior Researcher
A. S. Smailova
PCV «NCB»
Kazakhstan
Junior Researcher
Kazakhstan
Junior Researcher
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Review
For citations:
Babak V.A., Gusev A.A., Puntus I.A., Smailova A.S. METHOD OF DETERMINING THE IMMUNOGENIC ACTIVITY OF LIVE VACCINE AGAINST RABIES IN WILD ANIMALS IN MICE. Innovations and Food Safety. 2019;(2):53-57. (In Russ.) https://doi.org/10.31677/2311-0651-2019-24-2-53-57
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